The Endangered Roatán spiny-tailed iguana (Ctenosaura oedirhina) is found only on the islands of Roatán, Barbareta, and some surrounding cays. Although dense populations can be found in some privately protected locations, threats persist and management efforts are needed. The Roatán spiny-tailed iguana was first described in 1987 and since then informal and detailed studies have been conducted to better understand its biology and status. In 2010, a long-term monitoring program began, elucidating fluctuations in population dynamics and threats. This document presents a comprehensive five-year plan for the conservation and management actions considered essential to ensuring the long-term survival of Ctenosaura oedirhina in the wild. This plan combines knowledge and expertise from government, nongovernmental organizations, and the community of Roatán and greater Honduras, with the collective expertise of the IUCN SSC Iguana Specialist Group.