Trade and travel are the primary drivers of biological invasion both into and within the United States, and prevention measures have been identified as the most cost-effective means of minimizing the introduction and impact of invasive species. A recognized gap in the US government’s knowledge of the role that trade has played in the introduction of invasive species into the US led to a study undertaken by the US Environmental Protection Agency’s Office of International Affairs and IUCN. The aim was to identify the resources, strategies, and policies necessary to create, maintain, and make accessible one or more commodity/invasive species databases that EPA and other relevant agencies can apply to trade policy decision-making in a timely and scientifically-based manner.